Review Article (Open access)

SSR Inst. Int. J. Life Sci., 7(5): 2890-2900, Sep 2021

Prevalence of Anxiety and Depression in India among Medicos and Non-Medicos during Covid 19: A Survey

 

Meghna Gupta1, Vitull K Gupta2*, Navjot Kaur3, Parneet K Hari4, Kashish Goyal5

1Junior Resident, Department of psychiatry, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India

2Professor, Department of Medicine, Kishori Ram Hospital and Diabetes Care Centre, Bathinda, Punjab, India

3Associate Professor, Department of Pathology, Government Medical College, Amritsar, Punjab, India

4MBBS Intern, Government Medical College, Patiala, Punjab, India

5MBBS Intern Dayanand Medical College, Ludhiana, Punjab, India

 

*Address for Correspondence: Dr. Vitull K Gupta, Professor, Department of Medicine, Kishori Ram Hospital and Diabetes Care Centre, Bathinda-151001, Punjab, India

E-mail: vitullgupta2000@yahoo.com  

 

ABSTRACT- Background: Emerging evidence suggests a significant risk of mental health issues been associated with disease pandemics in past and during the present COVID-19 pandemic. Generalised anxiety disorders and depression are considered one of the most common mental disorders and there is a paucity of studies documenting their prevalence during the COVID-19 pandemic.

Methods: We conducted this survey using completely voluntary anonymous Generalized Anxiety Disorder Questionnaire-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) by distributing hard copies and e-copies after ethical approval. The anonymous survey questionnaire included socio-demographic characteristics like age, gender, medico or non-medico and residence in Punjab or outside Punjab.

Results: A total of 4333 subjects completed the survey. The prevalence of anxiety in the study population was 80.5% including 79.3% among medicos and 81.9% among non-medicos. The prevalence of depression in the study population was 73.3% including 74.7% among medicos and 71.7% among non-medicos. Most of the study population, medicos and non-medicos had mild anxiety and minimal depression as compared to another level of severity of anxiety and depression.

Conclusion: Our survey shows the high prevalence of anxiety and depression as compared to other studies documented in the literature, necessitating an increased focus on mental health issues and their psychological impacts to contain and curb grave adverse effects of anxiety and depression along with the need for early diagnosis and appropriate management of mental health disorders.

Key Words: Anxiety, COVID-19, Depression, Minimal depression, Prevalence, SARS-CoV-2


INTRODUCTION- In December 2019 origin of a coronavirus strain called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) was reported at Wuhan in China in a Hunan seafood market [1] and on 20 January 2020, the human-to-human transmission was reported and confirmed.[2]  On 30 January 2020, World Health Organisation (WHO) declared COVID-19 as a Public Health Emergency of International Concern and the first case was reported in India. On March 11, 2020, WHO declared the COVID-19 outbreak as a global pandemic [3] and on 23.3.2020 a complete lockdown was enforced by the government of India. Evidence suggests that severe psychological problems have been associated with disease pandemics in past and a systematic review has shown that loneliness and social isolation was associated with worse mental health outcomes.[4] Moreover, the COVID-19 pandemic forcing complete lockdown caused enormous human suffering and adversely affecting the economy causing universal psychosocial impact.[5] Globally, emerging evidence shows that the COVID pandemic presents a significant risk of mental health issues and is recognized as an important mental health care challenge.[6]

The psychological reaction of the population to any pandemic or disease outbreak plays an important role in managing the disease pandemic. Despite these facts, sufficient measures or resources were not provided for attenuating pandemics’ effects on the psychological health and wellbeing of the population.[7] In pre-COVID-19 times, some population-based studies and the National Mental Health Survey (2015-16) have documented the prevalence of anxiety and depression in India.[8] Generalized Anxiety Disorder Questionnaire-7 (GAD-7) [9] and Patient Health Questionnaire-9 (PHQ-9) [10] are effective screening tools found to be useful for a diagnosis of GAD and depression, especially in epidemiological studies and surveys. Preliminary evidence presented by a review of 28 research articles showed 16-28% symptoms of anxiety and depression during the COVID-19 pandemic. [11] A systematic review and meta-regression analysis of 29 studies using different assessment scales showed 25.8% (95% CI 20.5–31.9%) prevalence of anxiety, 24.3% (95% CI 18.2–31.6%) prevalence of depression among hospital staff engaged in COVID-19 care.[12] There is a paucity of quantifiable information, which was important for policymakers to make the appropriate policies to address increasing mental health problems. [13] So we conducted this survey to evaluate the prevalence of anxiety and depression among the general population including medicos and non-medicos in India.

 

MATERIALS AND METHODS


We conducted this survey between 1st October 2020 to 20th February 2021 to assess the prevalence of anxiety and depression in the Indian population during COVID 19 pandemic using hard copies and e-copies of the completely voluntary anonymous questionnaire.

 

Inclusion criteria- Willingness to participate, Age more than 18 years, Ability to read and understand English.

 

Exclusion criteria- Not consenting to participate, Age less than 18 years, Unable to read and understand English.

The anonymous survey questionnaire included socio-demographic characteristics like age, gender, medico or non-medico and residence in Punjab or outside Punjab. Anxiety and depression symptoms were assessed by using GAD-7 [9] and PHQ-9 scales.[10] GAD-7 contained seven questions and PHQ-9 contained nine questions to access severity on a 4-point scale of 0–3 ( 0- not at all, 1- several days, 2- more than half the day, 3- nearly every day) rating the symptoms in past two weeks. GAD-7 score of 0-no anxiety, 1-5 mild anxiety, 6-10 moderate anxiety and >11 severe anxiety. [9] PHQ-9 score of 0- no depression, 1–4- minimal depression, 5–9- mild depression, 10–14- moderate depression, 15–19- moderately severe depression and a score of 20–27 indicated severe depression.[10]  The GAD-7 and PHQ-9 have been documented as a valid and reliable screening tools used in research studies related to Middle East respiratory syndrome (MERS), Ebola outbreak and covid-19 in China [9,14].

 

Ethical Approval- Ethical approval was obtained from the Institutional Ethical Committee.

 

Statistical Analysis- Data was represented as frequency and percentage. Association of levels of scores with socio-demographic variables represented as frequency and percentage was calculated using Chi-Square Test. P value less than 0.05 was taken as statistically significant whereas P value more than 0.001 was taken as highly significant. All the analysis was done using 'IBM SPSS Statistics for Windows, version 23.0 (IBM Corp., Armonk, N.Y., USA)’.

 


RESULT

Socio-demographic characteristics- Table 1 shows the socio-demographic characteristics of the study population. A total of 4333 subjects participated in the survey, out of which 2246 (51.8%) were medicos and 2087 (48.2%) were non-medicos. Study population included 2741(63.3%) males and 1592 (36.7%) females. Medicos group included 1513 (55.2%) males and 733 (46%) females, whereas non-medicos group included 1228 (44.8%) males and 859 (54%) females. 2335 (53.9%) study subjects belonged to Punjab region including 634 (27.2%) medicos and 1701 (72.8%) non-medicos. 1998 (46.1%) study subjects were from out of Punjab region including 1612 (80.7%) medicos and 386 (19.3%) non-medicos.

 

Table 1:  Socio-demographic characteristics of the study population, medicos and non-medicos according to the age groups [N (%)]

Variables

Study Population

Medicos

Non- Medicos

Total

4333

2246 (51.8)

2087 (48.2)

 

 

Age  Group

20-40 years

Total

2080

972 (46.7)

1108 (53.3)

Gender

Male

1190

568 (47.7)

622 (52.3)

Female

890

404 (45.4)

486 (54.6)

Region

Punjab

1210

275 (22.7)

935 (77.3)

Out of Punjab

870

697 (80.1)

173 (19.9)

 

Total

1854

1027 (55.4)

827 (44.6)

Age  Group

41-60 years

Gender

Male

1246

748 (60.0)

498 (40.0)

Female

618

279 (45.1)

339 (54.9)

Region

 

Punjab

920

292 (31.7)

628 (68.3)

Out of Punjab

854

735 (86.1)

119 (13.9)

Total

399

247 (61.9)

152 (38.1)

Gender

Male

305

197 (64.6)

108 (35.4)

Age  Group

>60 years

Female

94

50 (53.2)

44 (46.8)

Region

Punjab

205

67 (32.7)

138 (67.3)

Out of Punjab

194

180 (92.8)

14 (7.2)

 

Prevalence of anxiety and depression- Table 2 shows the prevalence of anxiety (score >1 on GAD-7) in the study population was 80.5% (95% CI 72.50-88.50) and the difference of prevalence of anxiety among socio-demographic variables was observed to be statistically highly significant in all sub-groups except region group where it was statistically significant. The prevalence of depression (score >1 on PHQ-9) in the study population was 73.3% (95% CI 64.30-82.30) and the difference in the prevalence of depression among socio-demographic variables was statistically highly significant except the subgroup of the region where it was statistically non-significant.

 

Table 2: Prevalence of anxiety and depression according to various socio-demographic variables in study population N (%)

 

Variables

No Anxiety 

Anxiety

 

x2 value

P-value

No Dep.

 

Dep.

 

x2 value

P-value

 

Total

843

(19.5)

3490

 (80.5)

 

1159

(26.7)

3174

(73.3)

 

Age

20-40 Yrs

409

 (19.7)

1671

(80.2)

65.81

<0.001**

576

(27.7)

1504

(72.3)

16.52

<0.001**

41-60 Yrs

299

 (16.1)

1555

 (83.9)

449

 24.2)

1405

(75.8)

>60 yrs

135

(33.8)

264

(66.2)

134

(33.6)

265

(66.4)

Gender

Male

596

(21.7)

2145

 (78.3)

24.93

<0.001**

830

(30.3)

1911

(69.7)

47.52

<0.001**

Female

247

(15.5)

1345

 (84.5)

329

(20.7)

1263

(79.3)

Region

Punjab

420

(18.0)

1915

 (82.0)

6.966

0.008*

636 (27.2)

1699

(72.8)

0.619

0.431; NS

Out of Punjab

423

 (21.2)

1575

 (78.8)

523

(26.2)

1475

(73.8)

 

GAD-7 Scale: Score 0 No Anxiety, >1 Anxiety. PHQ-9 Scale: Score 0 No Depression (Dep), > 1 Depression (Dep). P Value: ** Statistically highly significant (p < 0.001), * Statistically significant (p < 0.05),

Statistically non- significant (p>0.05) (NS)

 

Table 3: Confidence Interval (CI) for anxiety and depression in the study population and according to variables

 

No Anxiety 

Anxiety

No Depression

Depression

Variables

95% CI

95% CI

95% CI

95% CI

 

Lower

Upper

Lower

Upper

Lower

Upper

Lower

Upper

 

Total

11.50

27.50

72.50

88.50

17.70

35.70

64.30

82.30

Age

20-40 Yrs

11.70

27.70

72.30

88.30

18.70

36.70

63.30

81.30

41-60 Yrs

9.10

23.10

76.90

90.90

16.20

32.20

67.80

83.80

>60 yrs

24.80

42.80

57.20

75.20

24.60

42.60

57.40

75.40

Gender

Male

13.70

29.70

70.30

86.30

21.30

39.30

60.70

78.70

Female

8.50

22.50

77.50

91.50

12.70

28.70

71.30

87.30

Region

Punjab

10.00

26.00

74.00

90.00

18.20

36.20

63.80

81.80

Out of Punjab

13.20

29.20

70.80

86.80

17.20

35.20

64.80

82.80

 

GAD-7 Scale: Score 0 No Anxiety, >1 Anxiety. PHQ-9 Scale: Score 0 No Depression, > 1 Depression

 

Table 4 shows the prevalence of anxiety among medicos was 79.3% and 81.9% among non-medicos and the difference was statistically significant. Prevalence of anxiety between medicos and non-medicos shows the statistically significant difference in sub-groups of 41-60 years age group, > 60 years age group and females whereas in subgroups of 20-40 years age group, males, region both Punjab and outside Punjab, the difference was statistically not-significant. The prevalence of depression among medicos was 74.7% and 71.7% among non-medicos and the difference was statistically significant, whereas the difference was statistically highly significant in sub-groups of 20-40 years age group and males, statistically significant difference in females, those residing in Punjab and the difference was statistically non-significant in 41-60 years age group, > 60 years age group and those residing outside Punjab.

 

Table 4: Prevalence of anxiety and depression according to various socio-demographic variables among medicos and non-medicos N (%)

Variables

Anxiety (Score >1)

Depression  (Score >1)

Medicos

Non-Medicos

x2 value

P value

Medicos

Non-Medicos

x2 value

P value

 

Total

1780 (79.3)

1710 (81.9)

4.972

0.026*

1677 (74.7)

1497 (71.7)

4.760

0.029*

Age

20-40 Yrs

790 (81.3)

881 (79.5)

1.019

0.313; NS

744 (76.5)

760 (68.6)

16.348

<0.001**

41-60 Yrs

838 (81.6)

717 (86.7)

8.816

0.003*

773 (75.3)

632 (76.4)

0.332

0.565; NS

>60 yrs

152 (61.5)

112 (73.7)

6.200

0.013*

160 (64.8)

105 (69.1)

0.781

0.377; NS

Gender

Male

1182 (78.1)

963 (78.4)

0.035

0.851; NS

1121 (74.1)

790 (64.3)

30.578

<0.001**

Female

598 (81.6)

747 (87.0)

8.730

0.003*

556 (75.9)

707 (82.3)

10.043

0.002*

Region

Punjab

513 (80.9)

1402 (82.4)

0.711

0.399; NS

484 (76.3)

1215 (71.4)

5.623

0.018*

Out of Punjab

1267 (78.6)

308 (79.8)

0.266

0.606; NS

1193 (74.0)

282 (73.1)

0.146

0.703; NS

 

P Value: ** Statistically highly significant (p < 0.001), * Statistically significant (p < 0.05), Statistically non-significant (p>0.05) (NS)

Prevalence of anxiety and depression according to severity score: Table 5 shows that 9.5% of subjects had no anxiety, 42.1% mild anxiety, 31.6% moderate and 6.9% subjects had severe anxiety. The comparison among different sub-groups of socio-demographic variables showed a statistically highly significant difference in all sub-groups except the sub-group of the region where it was statistically significant.

Table 5:  Prevalence of anxiety (GAD-7 scale) according to severity among socio-demographic variables in the study population N (%)

 

Variables

Study Population

x2 value

P-value

 

No anxiety

Mild anxiety

Moderate anxiety

Severe anxiety

Total

843 (19.5%)

1823 (42.1%)

1369 (31.6%)

298 (6.9%)

 

 

Age Groups

20-40 Yrs

409 (19.7%)

897 (43.1%)

616 (29.6%)

158 (7.6%)

90.920

<0.001**

41-60 Yrs

299 (16.1%)

800 (43.1%)

653 (35.2%)

102 (5.5%)

>60 yrs

135 (33.8%)

126 (31.6%)

100 (25.1%)

38 (9.5%)

Gender

Male

596 (21.7%)

1345 (49.1%)

662 (24.2%)

138 (5%)

274.545

<0.001**

Female

247 (15.5%)

478 (30%)

707 (44.4%)

160 (10.1%)

Region

Punjab

420 (18%)

1022 (43.8%)

735 (31.5%)

158 (6.8%)

9.186

0.027*

Out of Punjab

423 (21.2%)

801 (40.1%)

634 (31.7%)

140 (7%)

 

GAD-7 scale: Score 0: no Anxiety, 1-5 mild anxiety, 6-10 moderate anxiety and >11 severe anxiety

P Value: ** Statistically highly significant (p < 0.001), * Statistically significant (p < 0.05),

Statistically non- significant (p>0.05) (NS)

 

Table 6 shows the prevalence of anxiety according to severity score in medicos and non-medicos groups and various socio-demographic sub-groups. The difference in severity score of anxiety among medicos and non-medicos was statistically highly significant and in different sub-groups of socio-demographic variables, the difference was statistically highly significant in all sub-groups and statistically not-significant in subgroup of the Punjab region.

 

Table 6:  Prevalence of anxiety according to severity among the socio-demographic variables and in medicos and non-medicos N (%)

 

Variables

Medicos

Non-Medicos

x2 value

P value

Mild anxiety

Moderate anxiety

Severe

anxiety

Mild anxiety

Moderate anxiety

Severe

anxiety

Total

904 (40.2)

690 (30.7)

186 (8.3)

919 (44.0)

679 (32.5)

112 (5.4)

22.179

<0.001**

Age Groups

20-40 Yrs

386 (39.7)

312 (32.1)

92 (9.5)

511 (46.1)

304 (27.4)

66 (6.0)

17.937

<0.001**

41-60 Yrs

426 (41.5)

340 (33.1)

72 (7.0)

374 (45.2)

313 (37.8)

30 (3.6)

21.337

<0.001**

>60 yrs

92 (37.2)

38 (15.4)

22 (8.9)

34 (22.4)

62 (40.8)

16 (10.5)

35.189

<0.001**

Gender

Male

664 (43.9)

420 (27.8)

98 (6.5)

681 (55.5)

242 (19.7)

40 (3.3)

50.676

<0.001**

Female

240 (32.7)

270 (36.8)

88 (12.0)

238 (27.7)

437 (50.9)

72 (8.4)

33.434

<0.001**

Region

Punjab

265 (41.8)

193 (30.4)

55 (8.7)

57 (44.5)

542 (31.9)

103 (61)

6.337

0.096(NS)

Out of Punjab

639 (39.6)

497 (30.8)

131 (8.1)

162 (42)

137 (35.5

9 (2.3)

17.689

0.001*

GAD-7 scale: Score 0: no Anxiety, 1-5 mild anxiety, 6-10 moderate anxiety and >11 severe anxiety

P Value: ** Statistically highly significant (p < 0.001), * Statistically significant (p < 0.05),

Statistically non- significant (p>0.05) (NS)

 

The overall prevalence of depression according to severity score in the study population as well as among various socio-demographic sub-groups is expressed in Table 7. The difference severity score of depression among all the sub-groups of socio-demographic variables was statistically highly significant except in sub-groups of the region where the difference was statistically non-significant.

 

Table 7: Prevalence of Depression According to Severity among the Socio-demographic Variables in study population N (%)

 

Study Population

 

 

Variables

Minimal

Depression

Mild

Depression

Moderate Depression

Moderately Severe Dep.

Severe

Depression.

x2 value

P value

Total

1681(38.8%)

1218 (28.1%)

229 (5.3%)

45 (1%)

1 (0.02%)

 

 

Age Groups

20-40 Yrs

767 (36.9%)

575 (27.6%)

132 (6.3%)

30 (1.4%)

0 (0.0)

43.095

<0.001**

41-60 Yrs

786 (42.4%)

527 (28.4%)

81 (4.4%)

10 (0.5%)

1 (0.1%)

>60 yrs

128 (32.1%)

116 (29.1%)

16 (4%)

5 (1.3%)

0 (0.0)

Gender

Male

1174 42.8%)

610 (22.3%)

109 (4%)

17 (0.6%)

1 (0.04%)

194.431

<0.001**

Female

507 (31.8%)

608 (38.2%)

120 (7.5%)

28 (1.8%)

0 (0.0)

Region

Punjab

908 (38.9%)

633 (27.1%)

132 (5.7%)

26 (1.1%)

0 (0.0)

5.009

0.415; NS

Out of Punjab

773 (38.7%)

585 (29.3%)

97 (4.9%)

19 (1%)

1 (0.1%)

 

PHQ-9 Scale: Score 0 no Depression, 1-4: Minimal depression, 5-9: Mild depression, 10-14: Moderate depression, 15-19; Moderately severe depression, 20-27: Sever depression.

P Value: **Statistically highly significant (p<0.001), *Statistically significant (p<0.05), Statistically non- significant (p>0.05) (NS)

 

The overall prevalence of depression according to severity score in medicos and non-medicos and among various socio-demographic sub-groups is expressed in Table 8. The difference in severity score of depression between medicos and non-medicos was statistically significant. Among different sub-groups of socio-demographic variables, a statistically highly significant difference was observed in subgroups of 20-40 years age, > 60 years of age and males, whereas among females and Punjab region, the difference was statistically significant. Statistically, a non-significant difference was found in sub-groups of 41-60 years of age and out of the Punjab region.

 

Table 8: Prevalence of depression according to severity among the socio-demographic variables in medicos and non-medicos N (%)

 

Variables

Medicos

Non-Medicos

x2 value

 

P-value

Minimal Dep

Mild Dep

 

Mod Dep

 

Mod severe Dep

Minimal Dep

 

Mild

Dep

 

Mod Dep

 

Mod

severe

Dep

Total

895 (39.8)

621 (27.6)

130 (5.8)

30

(1.3)

786 (37.7)

597 (28.6)

99

(4.7)

15

 (.7)

12.300

0.031*

Age Groups

20-40 Yrs

361 (37.1)

291 (29.9)

75

(7.7)

17

(1.7)

406 (36.6)

284 (25.6)

57

(5.1)

13

(1.2)

21.915

<0.001**

41-60 Yrs

434 (42.3)

283 (27.6)

47

(4.6)

8

 (0.8)

352 (42.6)

244 (29.5)

34

(4.1)

2

 (.2)

4.356

0.49 (NS)

>60 yrs

100 (40.5)

47 (19. 0)

8

(3.2)

5

(2.0)

28

(18.4)

69 (45.4)

8

(5.3)

0

(0)

41.337

<0.001**

Gender

Male

658 (43.5)

375 (24.8)

75

(5.0)

12

 (.8)

516 (42.0)

235 (19.1)

34

(2.8)

5

(.4)

41.981

<0.001**

Female

237 (32.3)

246 (33.6)

55

(7.5)

18

 (2.5)

270 (31.4)

362 (42.1)

65

(7.6)

10

(1.2)

19.448

0.001*

Region

Punjab

274 (43.2)

154 (24.3)

45

(7.1)

11

 (1.7)

634 (37.3)

479 (28.2)

87

(5.1)

15

(9)

17.073

0.002*

Out of Punjab

621 (38.5)

467

(29)

85

(5.3)

19

(1.2)

152 (39.4)

118 (30.6)

12

(3.1)

0

(0)

8.232

0.14(NS)

PHQ-9 Scale: Score 0 no Depression, 1-4: Minimal depression (Dep), 5-9: Mild depression (Mild Dep), 10-14: Moderate depression (Mod Dep), 15-19; Moderately severe depression (Mod severe Dep), 20-27: Sever depression.

P Value: ** Statistically highly significant (p<0.001), *Statistically significant (p<0.05), Statistically non- significant (p>0.05) (NS)

 

Response to the question about difficulties to do work, takes care of things at home, or get along with other people show that 57.9 % (2510), 63.7% (1431) and 51.7% (1079) of the total study population, medico and non-medicos respectively did not have any difficulty at all to do work, takes care of things at home, or get along with other people. Whereas somewhat difficulty was felt by 38.3% (1658), 32.4% (728) and 44.6% (930), much difficulty was felt by 3.0% (131), 3.1% (69) and 3.0% (62), extremely difficult was felt by 0.8% (34), 0.8% (18) and 0.8% (16) of total study population, medicos and non-medicos respectively. The difference was observed to be statistically highly significant (x2= 68.724; df= 3; p<0.001).

Response to the question about the need for treatment among the total study population, medicos and non-medicos showed that 69.9 % (3030), 66.7% (1497) and 73.5% (1533) of the total study population, medico and non-medicos respectively did not take any treatment for anxiety or depression.  27.2% (1177), 30.5% (684) and 23.6% (493) of total study population, medico and non-medicos respectively took occasional treatment, 2.9% (126), 2.9% (65) and 2.9% (61) of total study population, medico and non-medicos respectively took treatment regularly.  The difference between medicos and non-medicos was observed to be statistically highly significant. (x2= 25.750; df= 2; p < 0.001).

 

DISCUSSION- Historically, any disease pandemics are associated with serious psychological and mental health consequences. Evidence suggests mental health issues like stress, depression, anxiety, sleep disturbances, fear, anger and denial has escalated during the Covid-19 pandemic globally among general and vulnerable populations.[15] Assessment of mental health issues is important for planning strategies to prevent and manage mental health issues.

We conducted this survey to document the prevalence of anxiety and depression using GAD-7 and PHQ-9 scales respectively and found prevalence of anxiety in the study population was 80.5% including 79.3% medicos and 81.9% non-medicos whereas the prevalence of depression was 73.3% including 74.7% medicos and 71.7% non-medicos. There are paucities of studies from India exploring the prevalence of anxiety and depression during the COVID-19 pandemic making any comparison difficult, but the high prevalence of anxiety and depression in our study emphasizes the urgent need for strengthening the preventive, therapeutic and curative mental health care services in India. Depression and anxiety are the most common psychiatric disorders with a prevalence of 10% to 20% in the general population.[12] In China, one of the first studies during COVID-19 among essential workers documented 20.1% prevalence of anxiety accessed by Beck Anxiety Inventory (BAI) and 12.7% prevalence of depressive symptoms accessed by Beck Depression Inventory-II (BDI-II) [16], which is very low as compared to our study. Another study conducted in China showed moderate to severe anxiety symptoms in 28.8% and moderate to severe depressive symptoms in 16.5% of the respondents accessed by the Depression, Anxiety and Stress Scale (DASS-21).[17]

Among the general population, the prevalence of anxiety for found to be in the range of 2 to 37% in China, 7.2 to 11.5% in Italy, 1.2 to 4% in Spain and about 28% in India Whereas the prevalence of depression was reported to be in the range of 8.3 to 48.3% in China, 15.4 to 17% in Italy, 1.7% to 8.7% in Spain and about 25% in India accessed by using different tools for estimation of anxiety and depression, whereas we used GAD-7 and PHQ-9 scales.[13] A meta-analysis found 23.2% pooled prevalence of anxiety and 22.8% depression accessed by different scales including GAD-7 and PHQ-9 scales.[18] Another systematic review and meta-analysis involving 31 studies from South Asian countries reported 41.3% pooled prevalence of anxiety during COVID-19 accessed using different assessment scales. Similarly, 28 studies using different assessment scales reported 34.1% pooled prevalence of depression during COVID-19. GAD-7 and PHQ-9 were the most frequently used assessment scales.[19] Differences in the estimated overall prevalence of mental health disorders in various studies are thought to be because of different methodologies, population size, heterogeneity in study population and differences in diagnostic or screening criteria used.[20] GAD-7 accessed higher prevalence of anxiety (49.2%) compared to DASS-21 (34.2%) and HADS (32.8%) scales. Similarly, PHQ-9 accessed higher prevalence (34.7%) of depression as compared to DASS-21 (29.8%) and HADS (29.2%) [19] So the use of GAD-7 and PHQ-9 in our study may be the reason for very high prevalence of anxiety and depression. Studies from India and Singapore documented 15.7% and 10.6% prevalence of anxiety and depression among HCWs [21] and 64.7% reported from Turkey both studies using the DASS-21 scale.[22] Similarly, the study by Kazmi et al. [23] documented the highest prevalence of anxiety and depression of 57% and 61.1% respectively using the DASS-21 scale. Prevalence of anxiety and depression in a web survey from Brazil and Spain was shown to be 8.3% and 11.6% for depression and anxiety respectively using GAD-7 and PHQ-9 scales.[20] A cross-sectional study conducted in 359 South Indian medical students showed that 75.5% had anxiety symptoms accessed by GAD-7 scale and 74.6% had depression symptoms accessed by CES-D scale which were comparable to the results of our study. Another cross-sectional survey showed that 25.1% of the subjects were depressed and 28% were anxious over the last 3 weeks accessed by DASS-21 scale.[24] A meta-analysis documented 43.6% pooled prevalence of anxiety among HCWs and 40.7% among the general population, whereas the pooled prevalence of depression was (39%) higher in the general population than (29.9%) among HCWs.[19] This also is less as compared to our study. Another meta-analysis showed 73% prevalence of anxiety among Egyptian medical students, 50.1% prevalence of anxiety among Hong Kong nurses, 10.5% prevalence of anxiety in the general American population, 20.9% prevalence of depression among physicians which is less as compared to the prevalence of anxiety and depression among medicos group in our survey.[12] In our study, the prevalence of anxiety according to severity scales in medicos was 20.7% had no anxiety, 40.2% mild anxiety, 30.7% moderate and 8.3% severe anxiety whereas in the non-medicos group 18.1% had no anxiety, 44.0% mild anxiety, 32.5% moderate and 5.4% severe anxiety. The results of our study were somewhat high as compared to the study showing 34% mild anxiety, 20% moderate anxiety and 14.8% moderately severe anxiety and 6.7% showed symptoms of severe anxiety using GAD-7 scales.[5] Data analysis in our survey shows that in the medicos group, 25.3% had no depression, 39.8% had minimal depression, 27.6% mild depression, 5.8% moderate depression, 1.3% moderately severe depression and 0.0% suffered from severe depression whereas, among non-medicos group, 28.3% had no depression, 37.7% minimal depression, 28.6% mild depression, 4.7% moderate depression, 0.7% moderately severe depression and 0.0% had severe depression. The results of our study were high as compared to a study showing 30.1% had mild depression, 20.3% moderate depression, 15.3% moderately severe depression and 8.9% had severe depression symptoms using CES-D scales.[25] In our survey, according to gender, the prevalence of anxiety was 78.3% in males, 84.5% in females, including 78.1% in males and 81.6% in females among the medicos group, 78.4% in males and 87.3% in females among the non-medicos group. Almost similar prevalence was observed in South Indian medical students’ study where 73.5% males and 77.5% females showed the presence of anxiety symptoms using GAD-7 scales.[25] In our study prevalence of anxiety according to the level of severity was 43.9% mild anxiety, 27.8% moderate anxiety and 6.5% severe anxiety in males and 32.7% mild anxiety, 36.8% moderate anxiety and 12% severe anxiety in females among the medicos group. Among the non-medicos group, it was 55.5% mild anxiety, 19.7% moderate anxiety and 3.3% severe anxiety in males and 27.7% mild anxiety, 50.9% moderate anxiety and 8.4% severe anxiety in females. Prevalence of anxiety according to the level of severity in South Indian medical students' study was observed to be mild anxiety 38.7% males and 29.2% females, moderate anxiety in 17.7% males and 22.5% females,  moderately severe anxiety in 11.6% males and 17.9% females and severe anxiety was observed in  5.5% males and 7.9% female students using GAD-7 and CES-D scales.[25]  In our survey, the predominance of the prevalence of anxiety among females than males was observed, which was similar to the observation by the National mental health survey of India 2015–2016.[8]

Prevalence of depression related to gender observed in our study population was 69.7% in males, 79.3% in females and medicos group, the prevalence of depression was 74.1% in males and 75.9% in females whereas in the non-medicos group it was 64.3% in males and 82.3% in females. Prevalence of depression related to gender observed in South Indian medical students’ study using CES-D scales [25] was 72.9% in males and 76.4% in females with females showing more prevalence than males like in our study. In our study prevalence of depression according to the level of severity related to gender in medicos was observed to be minimal depression in 43.5% males, 32.3% females, mild depression in 24.8% males, 33.6% females, moderate depression in 5.0% males, 7.5% females, moderately severe depression in 0.8% males, 2.5% females and severe depression was observed in 0.1% males and 0.0% in females. Similarly in the non-medicos group minimal depression was observed in 42.0% males, 31.4% females, mild depression in 19.1% males, 42.1% females, moderate depression in 2.8% males, 7.6% females, moderately severe depression in 0.4% males, 1.2% females and severe depression was observed none of the males or females. Prevalence of depression according to the level of severity in South Indian medical students’ study [25]  related to gender showed that 72.9% males and 76.4% females had depression, including mild depression in 31.5% males, 28.6% females, moderate depression in 18.8% males, 21.9% females, moderately severe depression in 15.4% males, 15.2% females and severe depression was observed in 7.2% males and 10.7% females. The similar predominance of females over males had been documented by the National mental health survey of India 2015–2016.[8]   

There are paucities of studies comparing the prevalence of anxiety and depression based on region and our study observed 82.0% prevalence of anxiety in the Punjab group, 78.8% outside the Punjab group and the difference was statistically significant (0.008). The difference in the prevalence of anxiety in medicos and non-medicos according to the region was statistically not significant. Similarly, the prevalence of depression was observed to be 72.8.0% in the Punjab group and 73.8% outside the Punjab group and the difference was statistically not significant (0.431), whereas the difference of prevalence of depression in medicos and non-medicos according to the region was statistically significant (0.018)  in Punjab group and statistically not significant (0.703) outside Punjab groups. 

Data analysis show that 57.9% of the total study population, 63.7% medico and 51.7% non-medicos did not have any difficulty at all to do work, whereas somewhat difficulty was felt by 38.3 % of the total study population, 32.4% medico and 44.6% non-medicos, many difficulties were experienced by 3.0 % of the total study population, 3.0% medico and 3.1% non-medicos and the extremely difficult situation was experienced by 0.8% of the total study population, 0.8% medico and 0.8% non-medicos. The difference observed was statistically highly significant (x2= 68.724; df= 3; p<0.001). Data about the need for treatment by the study population showed that 69.9% of the total study population, 66.7% medicos and 73.5% non-medicos did not take any treatment for anxiety or depression, whereas 27.2% of the total study population, 30.5% medicos and 23.6% of non-medicos took occasional treatment and only 2.9% of the total study population, 2.9%medicos and 2.9% non-medicos took treatment regularly. The difference between medicos and non-medicos was observed to be statistically highly significant. (x2= 25.750; df= 2; p < 0.001)

Results of our study, necessitate initiation of measures to curb, decrease and minimize the increasing prevalence of mental health disorders and psychiatric morbidity during Covid-19 pandemic like psychological interventions, supports for high-risk population, education for identification of mental health issues, awareness of psychiatric symptoms, curbing media exposure, break from work, increased peer support and easy access to psychiatric help through different methods of social media and telemedicine will help in reducing the psychological and psychiatric morbidity.[26]  In India mental health scenario in the pre-COVID-19 era was grim with psychiatric issues becoming more complicated during the COVID-19 pandemic because of the high prevalence of pre-existing mental disorders, deficient mental health care infrastructure and help, huge deprived population, uncontrolled information and misinformation on social, electronic and print media.[27] Keeping in mind, India specific COVID and mental health conditions, Government of India (GOI)-MOHFW  issued Psycho-Social toll-free helpline-08046110007 and web portal providing access to stress coping strategies, advice, videos, meditation and yoga practices to help people especially the vulnerable section of society to take care of their mental health issues.

Very high prevalence of anxiety and depression documented by our study also justify the NIMHANS suggestion to form a 'Psychological intervention medical team’ competent to formulate mental health interventions strategies to address mental health issues during the COVID-19 pandemic.[28] Results of our survey suggest initiation of urgent measures to address mental health issues and their psychological impacts to contain and curb grave adverse effects of mental disorders including anxiety and depression.

 

CONCLUSIONS- Results of our survey suggest a high prevalence of anxiety and depression in the Indian population. More people were found to be suffering from mild anxiety and mild depression during the COVID-19 pandemic. Socio-demographic variables like age groups, gender, region and job status influenced the prevalence of anxiety and depression in the study population as well as among medico and non-medico groups. Results of our survey may be helpful for the policymakers and the government to initiate and device diagnostic, preventive and management strategies to address the psychological as well as psychiatric needs of the Indian population.  Because, the Mental Healthcare Act, 2017 guaranteed the right to mental health care for the Indian population, the findings of this survey will help identify mental health care needs during these challenging times of the COVID-19 pandemic to initiate appropriate measures to promote the mental well-being of our population with initiating infrastructure strengthening and recruiting sufficient mental health care professionals.

 

CONTRIBUTION OF AUTHORS

Research concept- Meghna Gupta, Vitull K Gupta, Navjot Kaur

Research design- Meghna Gupta, Vitull K Gupta, Navjot Kaur

Supervision- Meghna Gupta, Vitull K Gupta, Navjot Kaur

Materials- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Data collection- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Data analysis and Interpretation-  Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Literature search- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Writing article- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Critical review- Meghna Gupta, Vitull K Gupta, Navjot Kaur

Article editing- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

Final approval- Meghna Gupta, Vitull K Gupta, Navjot Kaur, Parneet K. Hari, Kashish Goyal

 

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