Mini Review Article (Open access) |
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SSR Inst. Int. J. Life Sci., 7(1):
2749-2753,
January 2021
Is Marine
ω-3 Long Chain Polyunsaturated Fatty Acids Intake, Natural Remedial
Measure for Combating Global COVID-19 Pandemic?: A Mini-Review
R Anandan1, M Rosemol Jacob1,2,
TS Fazil1, CN Ravishankar1, Suseela Mathew1*
1ICAR-Central
Institute of Fisheries Technology, Matsyapuri (PO), Cochin-682029, India
2Department
of Marine Biology, Microbiology and Biochemistry, Cochin University of Science
and Technology, Cochin-682016, India
*Address for
Correspondence: Dr. Suseela
Mathew, Principal Scientist and Head, Biochemistry and Nutrition Division,
ICAR-Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin-682029,
India
E-mail: suseela1962@gmail.com
ABSTRACT- COVID-19 is considered as the most public health
emergency of international concern and global scientific research is on the
fast track to reducing the rise of epidemic curves. Marine natural
bioactive molecules have been the starting point for the discovery of the most
important drugs. The marine oils rich in ω-3 long-chain polyunsaturated
fatty acids (ω-3 LCPUFAs), especially, eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) are well known to exert promising human healthcare
benefits such as cardioprotective, antilipidemic, anti-inflammatory, anticancer,
antiaging, antihypertensive, antidepression and antiarthritic
properties. Interestingly, the immunomodulatory and anti-inflammatory potential
of ω-3 LCPUFAs is capable of attenuating some of the COVID-19 mediated
pathophysiological abnormalities through inhibition of pro-inflammatory
processes. Understanding the basic mechanism of action of ω-3 LCPUFAs on
pathophysiological conditions associated with COVID -19 may help address the
pandemic related healthcare complications. Classical mechanism of action of ω-3 LCPUFAs
in exhibiting anti-inflammatory properties is probably through counteraction of
nuclear factor-kB activation, which is a transcription factor potentially
involved in COVID-19 mediated of proinflammatory cytokine production. Also,
dietary ω-3 LCPUFAs intake is well known to activate the generation of
resolvins and protectin, which in turn can suppress COVID-19 associated
inflammation responses. Considering the beneficial actions of dietary intake of
ω-3 LCPUFAs rich marine oils, this mini-review elaborates the physiologic and metabolic influences of ω-3
LCPUFAs on COVID-19 induced pathophysiological aberrations with
relevance to their biochemical and molecular functions.
Key
Words: COVID-19, Docosahexaenoic acid, Eicosapentaenoic acid,
ω-3 PUFA,
Sardinella longiceps
INTRODUCTION- COVID-19 is a new public health crisis intimidating the human
population with the emergence and spread of novel coronavirus causing the
severe acute respiratory syndrome. Scientific investigation on
pathogenic and pathophysiological processes associated with COVID-19 infection has
attracted the research community to explore the scope of natural resources to
counteract/reduce the incidence of the dreadful pandemic. Clarity has not yet
come whether a drug or a vaccine or food itself can be a promising candidate in
addressing the physiological concerns associated with COVID-19. Globally
scientific research programs are on the fast track to boost both innate and
acquired immunity responses among human population to fight against both the
present and future virulent strains of SARS-CoV-2.
Interestingly, the recent therapeutic interventions carried out worldwide with
oral supplementation of ω-3 LCPUFAs in controlling the incidence of COVID
-19 [1,2] has pointed out at our concept of food as medicine
regaining therapeutic attention in treating diseases/disorders.
Though
evolution depicts the origin of life from the sea with the subsequent
conquering of the terrestrial environment with desirable acquired
characteristics, it makes us rethink whether organisms in the land may still rely
more upon the marine environment for their healthcare purposes. It may not be a
surprise if scientific research soon finds a solution from ω-3 LCPUFAs
rich marine oils for successful counteraction of pathophysiological conditions
associated with COVID 19. Incidence of COVID-19 and associated complications
are relatively low in Kerala, India, which comprises of a larger number of
marine fish-eating population. It is high time to focus scientific research on
the biochemical and molecular mechanisms of ω-3 LCPUFAs concerning the
interaction of the infectious processes associated with COVID -19. Comparing
the levels of research on the effects of fish oil in nutrition, the scientific
understanding of the dietary influence of ω-3 LCPUFAs on immunological
functions during viral and/or bacterial infections is relatively scanty. In
this mini-review, the impact of ω-3
LCPUFAs on COVID-19 induced pathophysiological alterations has
been discussed with relevance to their biochemical and molecular functions [3].
Molecular mechanisms of action of
ω-3 LCPUFA against Covid-19- A better understanding
of virus-host interactions is essential to establish the novel therapeutic
applications of ω-3 LCPUFAs in controlling COVID-19 pandemic. Apart from
the common symptoms such as headache, cough,
fever, sputum production, and diarrhoea, the disease manifestation of COVID-19
illness includes RNAaemia, acute respiratory distress syndrome, acute cardiac
injury, and lung infection, which are due to inflammation-related systemic and
localized immune response [4]. It is not clear whether the mechanism
of action of ω-3 LCPUFAs on the
immune response is mainly attributed to inhibition of lipid microdomain
clustering or stimulation of B cell populations [5]. Moreover, its
role in the activation of surface markers and inhibition of nuclear factor-kB
induced cytokine storm cannot be overruled. It
is interesting to note that the inhibitory actions of ω-3 LCPUFAs
on the activities of membrane-bound
aminopeptidase, angiotensin-converting enzyme 2 (ACE2) [6], which
has been identified as a functional receptor for the binding of the spike
protein of the coronavirus to invade epithelial cells, may probably be
responsible for normalizing respiratory and cardiovascular complications in
COVID-19 patients [7].
The possible shutdown actions of ω
-3 LCPUFAs on the alternate mechanisms of
COVID-19 mediated cellular dysfunction, which include the imbalanced response
of T helper cells and cytokine storm, warrants a surprise research package for
immunological scientists [8]. Also probably the ω -3
LCPUFAs mediated eicosanoid production and generation of mediators like
resolvins [9] may be playing an important role in dissolving the
lipophilic capsid and destroying the virus. Modulation in the fatty acid
composition of the cell membrane of lymphocytes,
sphingolipid/cholesterol-enriched lipid domains, and membrane fluidity, which
play major roles in improving cell signalling, are the promising aspects of the
dietary influence of ω-3 LCPUFAs to be addressed in detail by the
nutrigenomic scientific community. The ω -3 LCPUFA metabolites are well
known to modulate eicosanoid production, gene expression, lipid raft
composition and T-cell signalling [10] (Fig. 1).
Fig. 1: Immune booster mechanism of action
of EPA and DHA
Fish oil mediated induction of TNF-α, IL-6 and
IFN-γ9 can make B cells more efficient in combating virulent
pathogens. Globally, the ageing associated
deficiency in ω-3 LCPUFAs concentrations in the cellular system of
brain, heart, lungs and kidney may be one of the major factors responsible for
the increased mortality rate noticed in the elderly population. Most
importantly, the COVID-19 associated coagulopathy and thrombosis could be
effectively managed with the help of the anticoagulant property of ω-3
LCPUFAs [11]. The anticoagulant function of ω-3 PUFA is possibly related to
the increased retention of uncarboxylated coagulation factors, which can be
considered as an independent mechanism of action of marine ω -3 LCPUFAs apart from the
regular hepatic synthesis of coagulation factors [12]. Dietary intake of fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) may attenuate
the COVID-19 lockdown mediated sedentary life style, which caused obesity and
memory decline in both young children and elderly population. The marine small
pelagic Indian oil sardine, Sardinella longiceps (Fig. 2), contains a
rich amount of EPA, and DHA (Fig. 3), which are well known for prevention of
myocardial infarction in human beings [13]. Supplementation of
ω-3 LCPUFAs could, not only boost innate and acquired immune systems
against COVID-19; but also reduce uncertainty regarding the management of the
complications that arise in the course of corona viral illness.
Fig. 2:
Indian oil sardine (Sardinella longiceps), a marine fish rich in
ω-3 LCPUFAs
Fig. 3: Gas Chromatographic Pattern of EPA and DHA in Sardinella longicep
CONCLUSIONS- In conclusion,
the immunomodulatory and anti-inflammatory potential of ω-3 LCPUFAs is possibly
proficient in diminishing COVID-19 associated pathophysiological irregularities
through inhibition of pro-inflammatory processes. The healthcare complications
related to the pandemic can be reduced, at least in part, through the dietary
intake of ω-3 LCPUFAs. The possible mechanism of action of dietary
ω-3 LCPUFAs is related to their ability to generate resolvins and
protectin, which in turn can subdue COVID-19 associated inflammation responses.
Natural biomolecules have been the starting point for the discovery of most
important drugs. Also finding out the possible research gaps on the basic
mechanism of action of ω-3 LCPUFAs on pathophysiological conditions
associated with COVID-19 may pave way for more focussed research addressing the
healthcare functions and therapeutic applications of fish oil.
Since India is one of the largest fish oil producers
and exporters in the world, it will be no wonder, if marine fish oils find a
place to boost the economy of India, the country which is considered as Global
Pharmaceutical Hub. Though the nutraceutical and therapeutic values of fish oil
are promising, there is an urgent need to carry out extensive research to
confirm the exact molecular mechanisms of ω-3 LCPUFAs in normalizing the
complications of COVID-19 in human beings.
ACKNOWLEDGEMENT- The
authors would like to express their sincere gratitude to ICAR for providing
funds to carry out the research work under ICAR-National Fellow Scheme. The
authors acknowledge the Director, ICAR-Central Institute of Fisheries
Technology (ICAR-CIFT), Cochin, Kerala, India for granting permission to
publish the data acquired from the study.
Research
concept-
Dr. R Anandan
Research
design-
Dr. R Anandan, Dr. Suseela Mathew
Supervision- Dr. R Anandan, Dr.
Suseela Mathew, Dr. CN Ravishankar
Materials- M Rosemol Jacob, TS Fazil
Data
collection- M Rosemol Jacob, TS Fazil
Data
analysis and Interpretation- TS Fazil,
Dr. R Anandan, Dr. Suseela Mathew
Literature
search- M Rosemol Jacob, Dr. R Anandan, Dr.
Suseela Mathew
Writing
article- M
Rosemol Jacob, Dr.
R Anandan, Dr. Suseela Mathew
Critical
review-
Dr. Suseela Mathew, Dr. CN Ravishankar
Article
editing- M
Rosemol Jacob, Dr.
R Anandan
Final approval- Dr. Suseela Mathew, Dr. CN Ravishankar
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